Ontology highlight
ABSTRACT:
SUBMITTER: Boulding T
PROVIDER: S-EPMC5758711 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Boulding T T McCuaig R D RD Tan A A Hardy K K Wu F F Dunn J J Kalimutho M M Sutton C R CR Forwood J K JK Bert A G AG Goodall G J GJ Malik L L Yip D D Dahlstrom J E JE Zafar A A Khanna K K KK Rao S S
Scientific reports 20180108 1
Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, cancer stem cells (CSCs), the tumour microenvironment, and therapeutic resistance in breast cancer. LSD1 induced pan-genomic gene expression in networks implicated in EMT and selectiv ...[more]