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Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials.


ABSTRACT: With growing interest in the gut microbiome, prebiotics and probiotics have received considerable attention as potential treatments for depression and anxiety. We conducted a random-effects meta-analysis of 34 controlled clinical trials evaluating the effects of prebiotics and probiotics on depression and anxiety. Prebiotics did not differ from placebo for depression (d?=?-.08, p?=?.51) or anxiety (d?=?.12, p?=?.11). Probiotics yielded small but significant effects for depression (d?=?-.24, p?

SUBMITTER: Liu RT 

PROVIDER: S-EPMC6584030 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials.

Liu Richard T RT   Walsh Rachel F L RFL   Sheehan Ana E AE  

Neuroscience and biobehavioral reviews 20190417


With growing interest in the gut microbiome, prebiotics and probiotics have received considerable attention as potential treatments for depression and anxiety. We conducted a random-effects meta-analysis of 34 controlled clinical trials evaluating the effects of prebiotics and probiotics on depression and anxiety. Prebiotics did not differ from placebo for depression (d = -.08, p = .51) or anxiety (d = .12, p = .11). Probiotics yielded small but significant effects for depression (d = -.24, p <   ...[more]

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