Ontology highlight
ABSTRACT:
SUBMITTER: Paillard M
PROVIDER: S-EPMC5760244 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Paillard Melanie M Csordás György G Szanda Gergö G Golenár Tünde T Debattisti Valentina V Bartok Adam A Wang Nadan N Moffat Cynthia C Seifert Erin L EL Spät András A Hajnóczky György G
Cell reports 20170301 10
Mitochondrial Ca<sup>2+</sup> uptake through the Ca<sup>2+</sup> uniporter supports cell functions, including oxidative metabolism, while meeting tissue-specific calcium signaling patterns and energy needs. The molecular mechanisms underlying tissue-specific control of the uniporter are unknown. Here, we investigated a possible role for tissue-specific stoichiometry between the Ca<sup>2+</sup>-sensing regulators (MICUs) and pore unit (MCU) of the uniporter. Low MICU1:MCU protein ratio lowered th ...[more]