Ontology highlight
ABSTRACT:
SUBMITTER: Zwama M
PROVIDER: S-EPMC5760665 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Zwama Martijn M Yamasaki Seiji S Nakashima Ryosuke R Sakurai Keisuke K Nishino Kunihiko K Yamaguchi Akihito A
Nature communications 20180109 1
AcrB is the major multidrug exporter in Escherichia coli. Although several substrate-entrances have been identified, the specificity of these various transport paths remains unclear. Here we present evidence for a substrate channel (channel 3) from the central cavity of the AcrB trimer, which is connected directly to the deep pocket without first passing the switch-loop and the proximal pocket . Planar aromatic cations, such as ethidium, prefer channel 3 to channels 1 and 2. The efflux through ...[more]