Ontology highlight
ABSTRACT:
SUBMITTER: Matsunaga Y
PROVIDER: S-EPMC5839741 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Matsunaga Yasuhiro Y Yamane Tsutomu T Terada Tohru T Moritsugu Kei K Fujisaki Hiroshi H Murakami Satoshi S Ikeguchi Mitsunori M Kidera Akinori A
eLife 20180306
The multidrug transporter AcrB transports a broad range of drugs out of the cell by means of the proton-motive force. The asymmetric crystal structure of trimeric AcrB suggests a functionally rotating mechanism for drug transport. Despite various supportive forms of evidence from biochemical and simulation studies for this mechanism, the link between the functional rotation and proton translocation across the membrane remains elusive. Here, calculating the minimum free energy pathway of the func ...[more]