Ontology highlight
ABSTRACT:
SUBMITTER: Zhan X
PROVIDER: S-EPMC5762316 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhan Xin X Yu Wenjie W Franqui-Machin Reinaldo R Bates Melissa L ML Nadiminti Kalyan K Cao Huojun H Amendt Brad A BA Jethava Yogesh Y Frech Ivana I Zhan Fenghuang F Tricot Guido G
Oncotarget 20171127 67
Many cancers, including multiple myeloma (MM), retain more cytosolic iron to promote tumor cell growth and drug resistance. Higher cytosolic iron promotes oxidative damage due to its interaction with reactive oxygen species generated by mitochondria. The variation of mitochondrial biogenesis in different stages of MM disease was evaluated using gene expression profiles in a large clinical dataset. Sixteen of 18mitochondrial biogenesis related gene sets, including mitochondrial biogenesis signatu ...[more]