BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma.
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ABSTRACT:
SUBMITTER: Moravcikova E
PROVIDER: S-EPMC5763244 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma.
Moravcikova Erika E Krepela Evzen E Donnenberg Vera S VS Donnenberg Albert D AD Benkova Kamila K Rabachini Tatiana T Fernandez-Marrero Yuniel Y Bachmann Daniel D Kaufmann Thomas T
International journal of cancer 20170807 10
As the genomic region containing the Bcl-2-related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non-small-cell lung carcinoma (NSCLC) tumors and matched lung tissues from 102 surgically treated patients. We show that BOK protein levels are significantly downregulated in NSCLC tumors as compared to lung tissues (p < 0.001). In particular, we found BOK downregulation in ...[more]
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