Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells.
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ABSTRACT:
SUBMITTER: Sen P
PROVIDER: S-EPMC5767226 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells.
Sen Partho P Kemppainen Esko E Orešič Matej M
Frontiers in molecular biosciences 20180109
Human peripheral blood mononuclear cells (PBMCs) are the key drivers of the immune responses. These cells undergo activation, proliferation and differentiation into various subsets. During these processes they initiate metabolic reprogramming, which is coordinated by specific gene and protein activities. PBMCs as a model system have been widely used to study metabolic and autoimmune diseases. Herein we review various omics and systems-based approaches such as transcriptomics, epigenomics, proteo ...[more]
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