Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC5770152 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Immunity 20161101 5
Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best available examples of the humoral immune response to HIV are providing important information for the development of therapies and prophylaxis for HIV-1 infection. Here, we report a CD4-binding site (CD4bs) antibody, named N6, that potently neutralized 98% of HIV-1 isolates, including 16 of 20 that were resistant to other members of its class. N6 evolved a mode of recognition such that its binding was not impac ...[more]