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Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field.

ABSTRACT: A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

SUBMITTER: Bakshi SF

PROVIDER: S-EPMC5773386 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field.

Bakshi Saira F SF Guz Nataliia N Zakharchenko Andrey A Deng Han H Tumanov Alexei V AV Woodworth Craig D CD Minko Sergiy S Kolpashchikov Dmitry M DM Katz Evgeny E

Nanoscale 20180101 3

A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enha ...[more]

PMID: 29297526

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