Ontology highlight
ABSTRACT:
SUBMITTER: Blumenfeld CM
PROVIDER: S-EPMC6054622 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Blumenfeld Carl M CM Schulz Michael D MD Aboian Mariam S MS Wilson Mark W MW Moore Terilynn T Hetts Steven W SW Grubbs Robert H RH
Nature communications 20180720 1
Chemotherapy agents are notorious for producing severe side-effects. One approach to mitigating this off-target damage is to deliver the chemotherapy directly to a tumor via transarterial infusion, or similar procedures, and then sequestering any chemotherapeutic in the veins draining the target organ before it enters the systemic circulation. Materials capable of such drug capture are yet to be fully realized. Here, we report the covalent attachment of genomic DNA to iron-oxide nanoparticles. W ...[more]