Ontology highlight
ABSTRACT:
SUBMITTER: Xin A
PROVIDER: S-EPMC5779087 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Xin Annie A Masson Frederick F Liao Yang Y Preston Simon S Guan Tianxia T Gloury Renee R Olshansky Moshe M Lin Jian-Xin JX Li Peng P Speed Terence P TP Smyth Gordon K GK Ernst Matthias M Leonard Warren J WJ Pellegrini Marc M Kaech Susan M SM Nutt Stephen L SL Shi Wei W Belz Gabrielle T GT Kallies Axel A
Nature immunology 20160307 4
T cell responses are guided by cytokines that induce transcriptional regulators, which ultimately control differentiation of effector and memory T cells. However, it is unknown how the activities of these molecular regulators are coordinated and integrated during the differentiation process. Using genetic approaches and transcriptional profiling of antigen-specific CD8(+) T cells, we reveal a common program of effector differentiation that is regulated by IL-2 and IL-12 signaling and the combine ...[more]