Ontology highlight
ABSTRACT:
SUBMITTER: Rao RR
PROVIDER: S-EPMC5836496 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Rao Rajesh R RR Li Qingsheng Q Odunsi Kunle K Shrikant Protul A PA
Immunity 20100107 1
The mechanisms underpinning integration of instructions that program naive CD8+ T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-I) T cells via phosphoinositide 3-kinase and STAT4 transcription factor pathways. Blocking mTOR activity by rapamycin reversed IL-12-induced effector functions because of loss of pe ...[more]