Amebaborne "Attilina massiliensis" Keratitis, France.
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ABSTRACT:
SUBMITTER: Battaini A
PROVIDER: S-EPMC5782871 | biostudies-literature |
REPOSITORIES: biostudies-literature
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| S-EPMC4734529 | biostudies-literature
Project description:Mycotic keratitis is a distressing infection and may lead to permanent blindness. Fifty two cases of suspected mycotic keratitis were studied from Jan 91 to Sep 94. Specimens were collected on swabs in 20 cases and by corneal scraping in 32 cases. Wet mount examination of the specimens revealed fungal elements in 8 (15.4%) cases, of which 3 specimens were collected on swabs and 5 by corneal scraping. Fungi were isolated from a total of 12 (23.1%) specimens 5 of which were obtained by swabs while 7 by corneal scraping. Important pathogens were Fusarium spp, Aspergillus spp, Candida albicans and Cephalosporium spp. Direct examination of the specimens was found to be less sensitive than culture for the diagnosis of mycotic keratitis.
| S-EPMC5530211 | biostudies-other
Project description:A 75-year-old male with a right eye history of chronic dry eye syndrome, glaucoma status post tube shunt, and Fuchs dystrophy status post Descemet stripping endothelial keratoplasty followed by penetrating keratoplasty (PKP) presented with a 2.7 × 4.2 mm corneal ulcer, culture positive for Shewanella algae and Klebsiella oxytoca. A topical antibiotic regimen of gentamicin 14 mg/mL and vancomycin 50 mg/mL was administered according to culture sensitivities. There was concurrent use of loteprednol 0.5% (Lotemax Gel, Bausch and Lomb, Rochester, NY, USA) and later addition of erythromycin 0.5% ointment. The corneal ulcer improved with antibiotic therapy but was complicated by poor patient follow-up. Descemetocele formation prompted PKP in the right eye. The graft was successful and visual acuity improved from a low of light perception to maximum of 20/200 Snellen.
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Project description:We report a case of Ulocladium atrum keratitis in a 43-year-old man. No predisposing event was known. He received natamycin and fluconazole drops and the infection resolved. The isolate was identified by morphological and rRNA gene sequence analyses. U. atrum is a dematiaceous hyphomycete not hitherto reported to infect humans.
| S-EPMC1393132 | biostudies-literature
Project description:Purpose:To describe four cases of concomitant herpes simplex keratitis (HSK) and autoimmune-associated ulcerative keratitis (UK) in patients with rheumatoid arthritis (RA). Observations:All patients developed HSK and UK while undergoing treatment for RA. The average age of onset for RA, UK and HSK was 49.3, 69.5 and 70.5 years, respectively. UK preceded HSK in three cases and followed HSK in one case. Two patients had bilateral UK and two had unilateral UK. HSK was unilateral in all cases. All the cases had been treated with immunosuppressive agents including steroid, methotrexate, calcineurin inhibitors, etanercept and tocilizumab at the onset of HSK. Every patient was treated for HSK with topical acyclovir ointment combined with oral valacyclovir. The final visual outcome was extremely poor despite intensive therapy. Conclusions and Importance:These cases raise the possibility that RA patients have an increased risk of HSK, and that HSK may tend to be severe in these patients because of their immunocompromised condition. Furthermore, the complication of HSK and UK in RA patients is difficult to treat because of the atypical clinical manifestation. Thus, the emergence of corneal ulcer, especially in patients with a long clinical history of RA, calls for careful follow-up.
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| PRJEB41413 | ENA