Ontology highlight
ABSTRACT:
SUBMITTER: Belkahla S
PROVIDER: S-EPMC5787424 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Belkahla Sana S Haq Khan Abrar Ul AU Gitenay Delphine D Alexia Catherine C Gondeau Claire C Vo Dang-Nghiem DN Orecchioni Stefania S Talarico Giovanna G Bertolini Francesco F Cartron Guillaume G Hernandez Javier J Daujat-Chavanieu Martine M Allende-Vega Nerea N Gonzalez Martin Villalba MV
Oncotarget 20171214 1
Changes in metabolism require the efflux and influx of a diverse variety of metabolites. The ABC superfamily of transporters regulates the exchange of hundreds of substrates through the impermeable cell membrane. We show here that a metabolic switch to oxidative phosphorylation (OXPHOS), either by treating cells with dichloroacetate (DCA) or by changing the available substrates, reduced expression of ABCB1, ABCC1, ABCC5 and ABCG2 in wild-type p53-expressing cells. This metabolic change reduced h ...[more]