Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC5787779 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Tang Jun J Sun Mengmeng M Shi Guiying G Xu Yanfeng Y Han Yunlin Y Li Xiang X Dong Wei W Zhan Lingjun L Qin Chuan C
Frontiers in immunology 20180124
Accumulating evidence suggests important functions for human Toll-like receptor 8 <i>in vivo</i> in tuberculosis and autoimmune diseases. However, these studies are limited by the lack of specific agonists and by the fact that the homology of TLR8 in human and mice is not sufficient to rely on mouse models. In this study, we examined the role of human TLR8 in the disease progression of experimental <i>Mycobacterium tuberculosis (Mtb)</i> infection, as well as the benefits provided by a TLR8 agon ...[more]