Ontology highlight
ABSTRACT:
SUBMITTER: Ruan L
PROVIDER: S-EPMC5788616 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ruan Lin L Wang Lei L Wang Xiaosong X He Ming M Yao Xiaoguang X
Oncotarget 20171211 2
The epigenetic factor SIRT1 can promote prostate cancer progression, but it is unclear whether SIRT1 contributes to neuroendocrine differentiation. In this study, we showed that androgen deprivation can induce reactive oxygen species production and that reactive oxygen species, in turn, activate SIRT1 expression. The increased SIRT1 expression induces neuroendocrine differentiation of prostate cancer cells by activating the Akt pathway. In addition, the interaction between Akt and SIRT1 is indep ...[more]