Ontology highlight
ABSTRACT:
SUBMITTER: Conciatori F
PROVIDER: S-EPMC5789373 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Conciatori Fabiana F Ciuffreda Ludovica L Bazzichetto Chiara C Falcone Italia I Pilotto Sara S Bria Emilio E Cognetti Francesco F Milella Michele M
Cancers 20180119 1
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-component complexes, mTORC1 and mTORC2, which interact with each other and with several elements of other signaling pathways. In the past few years, many new insights into mTOR function and regulation have ...[more]