Ontology highlight
ABSTRACT:
SUBMITTER: Dixit M
PROVIDER: S-EPMC5793923 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Dixit Mudit M Weitman Michal M Gao Jiali J Major Dan T DT
ACS catalysis 20161202 1
Terpene cyclases catalyze the highly stereospecific molding of polyisoprenes into terpenes, which are precursors to most known natural compounds. The isoprenoids are formed via intricate chemical cascades employing rich, yet highly erratic, carbocation chemistry. It is currently not well understood how these biocatalysts achieve chemical control. Here, we illustrate the catalytic control exerted by trichodiene synthase, and in particular, we discover two features that could be general catalytic ...[more]