Ontology highlight
ABSTRACT:
SUBMITTER: Messaritakis I
PROVIDER: S-EPMC5797076 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Messaritakis Ippokratis I Politaki Eleni E Koinis Fillipos F Stoltidis Dimitris D Apostolaki Stella S Plataki Maria M Dermitzaki Eleftheria-Kleio EK Georgoulias Vassilis V Kotsakis Athanasios A
Scientific reports 20180202 1
The aim of the study was to investigate the effect of 2<sup>nd</sup>-line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progression (n = 45) by CellSearch and double immunofluorescence using anti-CKs and anti-Ki67, anti-M30 or anti-Vimentin antibodies. Before treatment, CTCs were detected in 50% ...[more]