Dataset Information

Structural Connectivity Alterations Along the Alzheimer's Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-? and Tau.

ABSTRACT:

Background

Gray matter changes associated with the progression of Alzheimer's disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention, particularly during early or preclinical stages of the disease.

Objective

To identify the structural connectivity changes across the AD continuum.

Methods

We performed probabilistic tractography in a total of 183 subjects on two independent samples that include control (n?=?68) and preclinical AD individuals (n?=?28), patients diagnosed with mild cognitive impairment (MCI) due to AD (n?=?44), and AD patients (n?=?43). We compared the connectivity between groups, and with CSF A?42 and tau biomarkers.

Results

We observed disconnections in preclinical individuals, mainly located in the temporal lobe. This pattern of disconnection spread to the parietal and frontal lobes at the MCI stage and involved almost all the brain in AD. These findings were not driven by gray matter atrophy.

Discussion

Using tractography, we were able to identify white matter changes between subsequent disease stages and, notably, also in preclinical AD. Therefore, this method may be useful for detecting early and specific brain structural changes during preclinical AD stage.

SUBMITTER: Tucholka A

PROVIDER: S-EPMC5798529 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Structural Connectivity Alterations Along the Alzheimer's Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau.

Tucholka Alan A Grau-Rivera Oriol O Falcon Carles C Rami Lorena L Sánchez-Valle Raquel R Lladó Albert A Gispert Juan Domingo JD Molinuevo José Luis JL

Journal of Alzheimer's disease : JAD 20180101 4

<h4>Background</h4>Gray matter changes associated with the progression of Alzheimer's disease (AD) have been thoroughly studied. However, alterations in white matter tracts have received less attention, particularly during early or preclinical stages of the disease.<h4>Objective</h4>To identify the structural connectivity changes across the AD continuum.<h4>Methods</h4>We performed probabilistic tractography in a total of 183 subjects on two independent samples that include control (n = 68) and ...[more]

PMID: 29376852

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