Ontology highlight
ABSTRACT:
SUBMITTER: Haswell LE
PROVIDER: S-EPMC5799303 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Haswell Linsey E LE Corke Sarah S Verrastro Ivan I Baxter Andrew A Banerjee Anisha A Adamson Jason J Jaunky Tomasz T Proctor Christopher C Gaça Marianna M Minet Emmanuel E
Scientific reports 20180205 1
The battery of regulatory tests used to evaluate the risk of novel tobacco products such as heated tobacco products (THPs) presents some limitations including a bias towards the apical endpoint tested, and limited information on the mode of action. This is driving a paradigm shift to more holistic systems biology approaches. In this study, we used RNA-sequencing to compare the transcriptomic perturbations following acute exposure of a 3D airway tissue to the aerosols from two commercial THPs and ...[more]