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Formal (4 + 1)-Addition of Allenoates to o-Quinone Methides.

ABSTRACT: The first (4 + 1)-annulation of o-quinone methides with ?-branched allenoates as C1 synthons has been developed. This operationally simple protocol gives access to highly functionalized dihydrobenzofurans in an unprecedented fashion with excellent diastereoselectivities and high yields.

SUBMITTER: Zielke K 

PROVIDER: S-EPMC5799871 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Formal (4 + 1)-Addition of Allenoates to o-Quinone Methides.

Zielke Katharina K   Waser Mario M  

Organic letters 20180119 3

The first (4 + 1)-annulation of o-quinone methides with α-branched allenoates as C1 synthons has been developed. This operationally simple protocol gives access to highly functionalized dihydrobenzofurans in an unprecedented fashion with excellent diastereoselectivities and high yields. ...[more]

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