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Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice.


ABSTRACT: Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1-/- hematopoietic cells and Stat1-/- stromal cells, and that the presence of wild-type hematopoietic or stromal cells was sufficient to restore normal development of Stat1-/- B cells. These results suggest that B cells normally restrain norovirus replication in a cell autonomous manner, and that wild-type STAT1 is required to protect B cell development during infection.

SUBMITTER: Hsu CC 

PROVIDER: S-EPMC5801037 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice.

Hsu Charlie C CC   Meeker Stacey M SM   Escobar Sabine S   Brabb Thea L TL   Paik Jisun J   Park Heon H   Iritani Brian M BM   Maggio-Price Lillian L  

Virology 20171226


Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marro  ...[more]

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