Novel Therapies for Myelofibrosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Pettit K
PROVIDER: S-EPMC5808510 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Novel Therapies for Myelofibrosis.
Pettit Kristen K Odenike Olatoyosi O
Current hematologic malignancy reports 20171201 6
<h4>Purpose of review</h4>The purpose of the review was to provide a contemporary update of novel agents and targets under investigation in myelofibrosis in the Janus kinase (JAK) inhibitor era.<h4>Recent findings</h4>Myelofibrosis (MF) is a clonal stem cell disease characterized by marrow fibrosis and a heterogeneous disease phenotype with a variable degree of splenomegaly, cytopenias, and constitutional symptoms that significantly impact quality of life and survival. Overactive JAK/STAT signal ...[more]
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