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Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome.

ABSTRACT: We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.

SUBMITTER: Bellomo C

PROVIDER: S-EPMC5808793 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome.

Bellomo Carla C Korva Miša M Papa Anna A Mäkelä Satu S Mustonen Jukka J Avšič-Županc Tatjana T Vaheri Antti A Martinez Valeria P VP Strandin Tomas T

Open forum infectious diseases 20180117 2

We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS. ...[more]

PMID: 29450213

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