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Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome.

ABSTRACT: We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.

SUBMITTER: Bellomo C 

PROVIDER: S-EPMC5808793 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome.

Bellomo Carla C   Korva Miša M   Papa Anna A   Mäkelä Satu S   Mustonen Jukka J   Avšič-Županc Tatjana T   Vaheri Antti A   Martinez Valeria P VP   Strandin Tomas T  

Open forum infectious diseases 20180117 2

We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS. ...[more]

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