Ontology highlight
ABSTRACT:
SUBMITTER: Khodadoust MS
PROVIDER: S-EPMC5808925 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Khodadoust Michael S MS Olsson Niclas N Wagar Lisa E LE Haabeth Ole A W OA Chen Binbin B Swaminathan Kavya K Rawson Keith K Liu Chih Long CL Steiner David D Lund Peder P Rao Samhita S Zhang Lichao L Marceau Caleb C Stehr Henning H Newman Aaron M AM Czerwinski Debra K DK Carlton Victoria E H VE Moorhead Martin M Faham Malek M Kohrt Holbrook E HE Carette Jan J Green Michael R MR Davis Mark M MM Levy Ronald R Elias Joshua E JE Alizadeh Ash A AA
Nature 20170322 7647
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and class II molecules. We applied this approach to systematically characterize MHC ligand ...[more]