Ontology highlight
ABSTRACT:
SUBMITTER: Chiang JJ
PROVIDER: S-EPMC5815369 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chiang Jessica J JJ Sparrer Konstantin M J KMJ van Gent Michiel M Lässig Charlotte C Huang Teng T Osterrieder Nikolaus N Hopfner Karl-Peter KP Gack Michaela U MU
Nature immunology 20171127 1
The sensor RIG-I detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to have a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG-I during infection with a DNA virus are largely unknown. Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1). Infection with HSV-1 induced re ...[more]