Ontology highlight
ABSTRACT:
SUBMITTER: Monteverde T
PROVIDER: S-EPMC5815498 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Monteverde T T Tait-Mulder J J Hedley A A Knight J R JR Sansom O J OJ Murphy D J DJ
Oncogene 20171106 8
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability. As such, NUAK1 may play key roles in multiple diseases ranging from neurodegeneration to diabetes and metastatic cancer. Previous work revealed a crucial role for NUAK1 in supporting viability of tumour cells specifically when MYC is overexpressed. This role is surprising, given ...[more]