Ontology highlight
ABSTRACT:
SUBMITTER: Yoon JC
PROVIDER: S-EPMC3956149 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Yoon John C JC Ling Alvin J Y AJ Isik Meltem M Lee Dong-Young Donna DY Steinbaugh Michael J MJ Sack Laura M LM Boduch Abigail N AN Blackwell T Keith TK Sinclair David A DA Elledge Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20140220 10
Mitochondrial defects underlie a multitude of human diseases. Genetic manipulation of mitochondrial regulatory pathways represents a potential therapeutic approach. We have carried out a high-throughput overexpression screen for genes that affect mitochondrial abundance or activity using flow-cytometry-based enrichment of a cell population expressing a high-complexity, concentration-normalized pool of human ORFs. The screen identified 94 candidate mitochondrial regulators including the nuclear p ...[more]