Ontology highlight
ABSTRACT:
SUBMITTER: Zhurakovskyi O
PROVIDER: S-EPMC5817397 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Zhurakovskyi Oleksandr O Türkmen Yunus E YE Löffler Lorenz E LE Moorthie Vijayalakshmi A VA Chen C Chun CC Shaw Michael A MA Crimmin Mark R MR Ferrara Marco M Ahmad Mushtaq M Ahmad Mushtaq M Ostovar Mehrnoosh M Matlock Johnathan V JV Aggarwal Varinder K VK
Angewandte Chemie (International ed. in English) 20180109 5
A convergent, nine-step (LLS), enantioselective synthesis of α-cyclopiazonic acid and related natural products is reported. The route features a) an enantioselective aziridination of an imine with a chiral sulfur ylide; b) a bioinspired (3+2)-cycloaddition of the aziridine onto an alkene; and c) installation of the acetyltetramic acid by an unprecedented tandem carbonylative lactamization/N-O cleavage of a bromoisoxazole. ...[more]