Ontology highlight
ABSTRACT:
SUBMITTER: Souma T
PROVIDER: S-EPMC5819405 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Souma Tomokazu T Thomson Benjamin R BR Heinen Stefan S Carota Isabel Anna IA Yamaguchi Shinji S Onay Tuncer T Liu Pan P Ghosh Asish K AK Li Chengjin C Eremina Vera V Hong Young-Kwon YK Economides Aris N AN Vestweber Dietmar D Peters Kevin G KG Jin Jing J Quaggin Susan E SE
Proceedings of the National Academy of Sciences of the United States of America 20180122 6
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Using conditional knockout studies in mice, we show TIE2 is predominantly activated by ANGPT1 in the cardiovascular system and by ANGPT2 in the lymphatic vasculatur ...[more]