Dataset Information

Lung cancer and socioeconomic status in a pooled analysis of case-control studies.

ABSTRACT: An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study.Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens.The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61-2.09); ESeC OR 1.53 (95% CI 1.44-1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20-1.98); ESeC OR 1.34 (95% CI 1.19-1.52)).SES remained a risk factor for lung cancer after adjustment for smoking behavior.

SUBMITTER: Hovanec J

PROVIDER: S-EPMC5819792 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Lung cancer and socioeconomic status in a pooled analysis of case-control studies.

Hovanec Jan J Siemiatycki Jack J Conway David I DI Olsson Ann A Stücker Isabelle I Guida Florence F Jöckel Karl-Heinz KH Pohlabeln Hermann H Ahrens Wolfgang W Brüske Irene I Wichmann Heinz-Erich HE Gustavsson Per P Consonni Dario D Merletti Franco F Richiardi Lorenzo L Simonato Lorenzo L Fortes Cristina C Parent Marie-Elise ME McLaughlin John J Demers Paul P Landi Maria Teresa MT Caporaso Neil N Tardón Adonina A Zaridze David D Szeszenia-Dabrowska Neonila N Rudnai Peter P Lissowska Jolanta J Fabianova Eleonora E Field John J Dumitru Rodica Stanescu RS Bencko Vladimir V Foretova Lenka L Janout Vladimir V Kromhout Hans H Vermeulen Roel R Boffetta Paolo P Straif Kurt K Schüz Joachim J Kendzia Benjamin B Pesch Beate B Brüning Thomas T Behrens Thomas T

PloS one 20180220 2

<h4>Background</h4>An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study.<h4>Methods</h4>Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the Inte ...[more]

PMID: 29462211

Similar Datasets

Project description:BackgroundWhile much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents.ObjectivesWe investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e., nickel, chromium-VI), and polycyclic aromatic hydrocarbons (PAH) on lung cancer risk, overall and by major histologic subtype, while accounting for cigarette smoking.MethodsIn the international 14-center SYNERGY project, occupational exposures were assigned to 16,901 lung cancer cases and 20,965 control subjects using a quantitative job-exposure matrix (SYN-JEM). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed for ever vs. never exposure using logistic regression models stratified by sex and adjusted for study center, age, and smoking habits. Joint effects among pairs of agents were assessed on multiplicative and additive scales, the latter by calculating the relative excess risk due to interaction (RERI).ResultsAll pairwise joint effects of lung carcinogens in men were associated with an increased risk of lung cancer. However, asbestos/metals and metals/PAH resulted in less than additive effects; while the chromium-VI/silica pair showed marginally synergistic effect in relation to adenocarcinoma (RERI: 0.24; CI: 0.02, 0.46; p = 0.05). In women, several pairwise joint effects were observed for small cell lung cancer including exposure to PAH/silica (OR = 5.12; CI: 1.77, 8.48), and to asbestos/silica (OR = 4.32; CI: 1.35, 7.29), where exposure to PAH/silica resulted in a synergistic effect (RERI: 3.45; CI: 0.10, 6.8).DiscussionSmall or no deviation from additive or multiplicative effects was observed, but co-exposure to the selected lung carcinogens resulted generally in higher risk than exposure to individual agents, highlighting the importance to reduce and control exposure to carcinogens in workplaces and the general environment. https://doi.org/10.1289/EHP13380.

Dataset Information

Lung cancer and socioeconomic status in a pooled analysis of case-control studies.

Publications

Lung cancer and socioeconomic status in a pooled analysis of case-control studies.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets