Real-time monitoring of the aggregation of Alzheimer's amyloid-? via1H magic angle spinning NMR spectroscopy.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5820189 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Real-time monitoring of the aggregation of Alzheimer's amyloid-β via<sup>1</sup>H magic angle spinning NMR spectroscopy.
Wang Jian J Yamamoto Tomoya T Bai Jia J Cox Sarah J SJ Korshavn Kyle J KJ Monette Martine M Ramamoorthy Ayyalusamy A
Chemical communications (Cambridge, England) 20180201 16
Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation reveals that mechanical rotation of Aβ<sub>1-40</sub> monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species. EGCG's ability to shift off-pathway aggregation is also demonstrated. ...[more]
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