Dataset Information

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

ABSTRACT: OBJECTIVE:Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN. PATIENTS AND METHODS:Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide analyses were performed in relation to ?grade 3 Common Terminology Criteria for Adverse Events (CTCAE) neuropathy in European and African Americans. Data were meta-analyzed with GW associations of CTCAE ?grade 3 versus

SUBMITTER: Sucheston-Campbell LE

PROVIDER: S-EPMC5824720 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

Sucheston-Campbell Lara E LE Clay-Gilmour Alyssa I AI Barlow William E WE Budd G Thomas GT Stram Daniel O DO Haiman Christopher A CA Sheng Xin X Yan Li L Zirpoli Gary G Yao Song S Jiang Chen C Owzar Kouros K Hershman Dawn D Albain Kathy S KS Hayes Daniel F DF Moore Halle C HC Hobday Timothy J TJ Stewart James A JA Rizvi Abbas A Isaacs Claudine C Salim Muhammad M Gralow Jule R JR Hortobagyi Gabriel N GN Livingston Robert B RB Kroetz Deanna L DL Ambrosone Christine B CB

Pharmacogenetics and genomics 20180201 2

<h4>Objective</h4>Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN.<h4>Patients and methods</h4>Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide analyses were performed in relation to ≥grade 3 Common Terminology Criteria f ...[more]

PMID: 29278617

Dataset Information

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

Publications

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

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