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The selective electrochemical fluorination of S-alkyl benzothioate and its derivatives.


ABSTRACT: We herein report that the regioselective anodic fluorination of S-alkyl benzothioate and its derivatives in various aprotic solvents using Et3N·nHF (n = 3-5) and Et4NF·nHF (n = 3-5) as supporting electrolyte and a fluorine source successfully provided the corresponding ?-fluorinated products in moderate yields. Dichloromethane containing Et4NF·4HF was found to be the most suitable combination as electrolytic solvent and supporting salt as well as fluorine source for the anodic fluorination. The electrochemical fluorination of cyclic benzothioates such as benzothiophenone was also achieved.

SUBMITTER: Kuribayashi S 

PROVIDER: S-EPMC5827776 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The selective electrochemical fluorination of <i>S</i>-alkyl benzothioate and its derivatives.

Kuribayashi Shunsuke S   Kurioka Tomoyuki T   Inagi Shinsuke S   Lu Ho-Jung HJ   Uang Biing-Jiun BJ   Fuchigami Toshio T  

Beilstein journal of organic chemistry 20180212


We herein report that the regioselective anodic fluorination of <i>S</i>-alkyl benzothioate and its derivatives in various aprotic solvents using Et<sub>3</sub>N·<i>n</i>HF (<i>n</i> = 3-5) and Et<sub>4</sub>NF·<i>n</i>HF (<i>n</i> = 3-5) as supporting electrolyte and a fluorine source successfully provided the corresponding α-fluorinated products in moderate yields. Dichloromethane containing Et<sub>4</sub>NF·4HF was found to be the most suitable combination as electrolytic solvent and supporti  ...[more]

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