Ontology highlight
ABSTRACT:
SUBMITTER: Pauty J
PROVIDER: S-EPMC5828365 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Pauty Joris J Usuba Ryo R Cheng Irene Gayi IG Hespel Louise L Takahashi Haruko H Kato Keisuke K Kobayashi Masayoshi M Nakajima Hiroyuki H Lee Eujin E Yger Florian F Soncin Fabrice F Matsunaga Yukiko T YT
EBioMedicine 20171220
Angiogenesis is the formation of new capillaries from pre-existing blood vessels and participates in proper vasculature development. In pathological conditions such as cancer, abnormal angiogenesis takes place. Angiogenesis is primarily carried out by endothelial cells, the innermost layer of blood vessels. The vascular endothelial growth factor-A (VEGF-A) and its receptor-2 (VEGFR-2) trigger most of the mechanisms activating and regulating angiogenesis, and have been the targets for the develop ...[more]