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Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers.

ABSTRACT: Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (

SUBMITTER: Sanchez GJ

PROVIDER: S-EPMC5829637 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers.

Sanchez Gilson J GJ Richmond Phillip A PA Bunker Eric N EN Karman Samuel S SS Azofeifa Joseph J Garnett Aaron T AT Xu Quanbin Q Wheeler Graycen E GE Toomey Cathryn M CM Zhang Qinghong Q Dowell Robin D RD Liu Xuedong X

Nucleic acids research 20180201 4

Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (<GI50) predominantly resulted in upregulation of ...[more]

PMID: 29240919

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