Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez GJ
PROVIDER: S-EPMC5829637 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sanchez Gilson J GJ Richmond Phillip A PA Bunker Eric N EN Karman Samuel S SS Azofeifa Joseph J Garnett Aaron T AT Xu Quanbin Q Wheeler Graycen E GE Toomey Cathryn M CM Zhang Qinghong Q Dowell Robin D RD Liu Xuedong X
Nucleic acids research 20180201 4
Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investigated genome wide dose-dependent epigenetic and transcriptome changes in response to HDACI largazole in a transformed and a non-transformed cell line. Exposure to low nanomolar largazole concentrations (<GI50) predominantly resulted in upregulation of ...[more]