Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Rosa JM
PROVIDER: S-EPMC5830170 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
González-Rosa Juan Manuel JM Sharpe Michka M Field Dorothy D Soonpaa Mark H MH Field Loren J LJ Burns Caroline E CE Burns C Geoffrey CG
Developmental cell 20180201 4
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a correlation by demonstrating that experimental polyploidization of zebrafish cardiomyocytes is sufficient to suppress their proliferative potential during regeneration. Initially, we determined that zebrafish myocardium becomes susceptible to polyploidization upon transient cytokinesis inhibition mediated by dominant-ne ...[more]