Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC5830375 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Fang Xiao X Shen Feiyang F Lechauve Christophe C Xu Peng P Zhao Guowei G Itkow Jacobi J Wu Fan F Hou Yaying Y Wu Xiaohui X Yu Lingling L Xiu Huiqing H Wang Mengli M Zhang Ruiling R Wang Fangfang F Zhang Yanqing Y Wang Daxin D Weiss Mitchell J MJ Yu Duonan D
Haematologica 20171221 3
The microRNAs <i>miR-144</i> and -<i>451</i> are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the <i>miR-144/451</i> gene in mice causes mild anemia under baseline conditions. Here we show that <i>miR-144/451</i><sup>-/-</sup> erythroblasts exhibit increased apoptosis during recovery from acute anemia. Mechanistically, <i>miR-144/451</i> depletion increases the expression of the <i>miR-451</i> target mRNA <i>Cab39</i>, which ...[more]