Novel FR-900493 Analogues That Inhibit the Outgrowth of Clostridium difficile Spores.
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ABSTRACT:
SUBMITTER: Mitachi K
PROVIDER: S-EPMC5830699 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Novel FR-900493 Analogues That Inhibit the Outgrowth of <i>Clostridium difficile</i> Spores.
Mitachi Katsuhiko K Yun Hyun Gi HG Kurosu Sara M SM Eslamimehr Shakiba S Lemieux Maddie R MR Klaić Lada L Clemons William M WM Kurosu Michio M
ACS omega 20180209 2
The spectrum of antibacterial activity for the nucleoside antibiotic FR-900493 (<b>1</b>) can be extended by chemical modifications. We have generated a small focused library based on the structure of <b>1</b> and identified UT-17415 (<b>9</b>), UT-17455 (<b>10</b>), UT-17460 (<b>11</b>), and UT-17465 (<b>12</b>), which exhibit anti-<i>Clostridium difficile</i> growth inhibitory activity. These analogues also inhibit the outgrowth of <i>C. difficile</i> spores at 2× minimum inhibitory concentrat ...[more]
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