Ontology highlight
ABSTRACT:
SUBMITTER: Brodin JD
PROVIDER: S-EPMC5831182 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20151120 47
We report a strategy for creating a new class of protein transfection materials composed of a functional protein core chemically modified with a dense shell of oligonucleotides. These materials retain the native structure and catalytic ability of the hydrolytic enzyme β-galactosidase, which serves as the protein core, despite the functionalization of its surface with ∼25 DNA strands. The covalent attachment of a shell of oligonucleotides to the surface of β-galactosidase enhances its cellular up ...[more]