Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6566069 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zhang Yi Y Deng Yingnan Y Wang Congshan C Li Lidan L Xu Lida L Yu Yingjie Y Su Xin X
Chemical science 20190506 23
Given the essential role of apurinic/apyrimidinic endonuclease (APE1) in gene repair and cancer progression, we report a novel approach for probing and regulating cellular APE1 activity by using DNA tetrahedrons. The tetrahedron with an AP site-containing antenna exhibits high sensitivity and specificity to APE1. It is suitable for APE1 <i>in vitro</i> detection (detection limit 5 pM) and cellular fluorescence imaging without any auxiliary transfection reagents, which discriminates the APE1 expr ...[more]