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DNA nanotubes as combinatorial vehicles for cellular delivery.

ABSTRACT: This work explores using self-assembled DNA nanostructures as carriers for drug delivery. We have recently developed an organic nanotube system that is assembled from a single component: a 52-base-long DNA single strand. In this work, functional agents (folate as a cancer cell target agent and Cy3 as a fluorescence imaging agent) are conjugated with the DNA strands; the conjugates self-assemble into micrometers-long nanotubes (NTs). The conjugated DNA-NTs can be effectively taken by cancer cells as demonstrated by fluorescence imaging and fluorescence-activated cell sorting. No obvious toxicity has been observed under current experimental conditions.

SUBMITTER: Ko S

PROVIDER: S-EPMC2760450 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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DNA nanotubes as combinatorial vehicles for cellular delivery.

Ko SeungHyeon S Liu Haipeng H Chen Yi Y Mao Chengde C

Biomacromolecules 20080927 11

This work explores using self-assembled DNA nanostructures as carriers for drug delivery. We have recently developed an organic nanotube system that is assembled from a single component: a 52-base-long DNA single strand. In this work, functional agents (folate as a cancer cell target agent and Cy3 as a fluorescence imaging agent) are conjugated with the DNA strands; the conjugates self-assemble into micrometers-long nanotubes (NTs). The conjugated DNA-NTs can be effectively taken by cancer cells ...[more]

PMID: 18821795

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