Ontology highlight
ABSTRACT:
SUBMITTER: Burslem GM
PROVIDER: S-EPMC5831399 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell chemical biology 20171109 1
Proteolysis targeting chimera (PROTAC) technology has emerged over the last two decades as a powerful tool for targeted degradation of endogenous proteins. Herein we describe the development of PROTACs for receptor tyrosine kinases, a protein family yet to be targeted for induced protein degradation. The use of VHL-recruiting PROTACs against this protein family reveals several advantages of degradation over inhibition alone: direct comparisons of fully functional, target-degrading PROTACs with t ...[more]