Ontology highlight
ABSTRACT:
SUBMITTER: Yun J
PROVIDER: S-EPMC5833366 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cell death & disease 20180221 3
The low expression of tissue inhibitor of metalloproteinase 3 (TIMP-3) is important in inflammatory responses. Therefore, inhibition of TIMP-3 may promote tumor development. Our study showed that expression of TIMP-3 was elevated in lL-32γ mice lung tissues. In this study, we investigated whether IL-32γ mice inhibited lung tumor development through overexpression of TIMP-3 and its methylation. To explore the possible underlying mechanism, lung cancer cells were transfected with IL-32γ cDNA plasm ...[more]