Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC5834211 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zhu Qingyuan Q Tan Peng P Li Yinyin Y Lin Meng M Li Chaoran C Mao Jingrong J Cui Jun J Zhao Wei W Wang Helen Y HY Wang Rong-Fu RF
PLoS pathogens 20180220 2
Melanoma differentiation-associated gene-5 (MDA5) recognizes distinct subsets of viruses including Encephalomyocarditis virus (EMCV) of picornavirus family, but the molecular mechanisms underlying the specificity of the viral recognition of MDA5 in immune cells remain obscure. DHX29 is an RNA helicase required for the translation of 5' structured mRNA of host and many picornaviruses (such as EMCV). We identify that DXH29 as a key RNA co-sensor, plays a significant role for specific recognition a ...[more]