Ontology highlight
ABSTRACT:
SUBMITTER: Klosowski DW
PROVIDER: S-EPMC5834403 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Organic letters 20180212 5
The BINOL-amidine organic catalyst 1 was previously shown to promote highly efficient enantioselective halolactonization reactions of olefinic acids. As part of these studies, it was discovered that the enantioenriched iodolactones could be easily converted into enantioenriched cis-1,2-disubstituted epoxides. This halolactonization-epoxidation sequence was applied to the synthesis of (+)-disparlure, which resulted in the shortest catalytic enantioselective synthesis to date, requiring only five ...[more]