Ontology highlight
ABSTRACT:
SUBMITTER: Jin F
PROVIDER: S-EPMC5838364 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Jin Feng F Irshad Shazia S Yu Wei W Belakavadi Madesh M Chekmareva Marina M Ittmann Michael M MM Abate-Shen Cory C Fondell Joseph D JD
Molecular cancer research : MCR 20130328 7
MED1 is a key coactivator of the androgen receptor (AR) and other signal-activated transcription factors. Whereas MED1 is overexpressed in prostate cancer cell lines and is thought to coactivate distinct target genes involved in cell-cycle progression and castration-resistant growth, the underlying mechanisms by which MED1 becomes overexpressed and its oncogenic role in clinical prostate cancer have remained unclear. Here, we report that MED1 is overexpressed in the epithelium of clinically loca ...[more]