A scored human protein-protein interaction network to catalyze genomic interpretation.
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ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC5839635 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
A scored human protein-protein interaction network to catalyze genomic interpretation.
Li Taibo T Wernersson Rasmus R Hansen Rasmus B RB Horn Heiko H Mercer Johnathan J Slodkowicz Greg G Workman Christopher T CT Rigina Olga O Rapacki Kristoffer K Stærfeldt Hans H HH Brunak Søren S Jensen Thomas S TS Lage Kasper K
Nature methods 20161128 1
Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4 ...[more]
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